The Premier League duo go again after a hard-fought 0-0 draw at Molineux on Saturday where both sides missed chances to win the tie and Matt Doherty had a goal ruled out for offside.
So the tie heads to Old Trafford with the action live on air from 7.15pm on BT Sport 1 and BT Sport Ultimate for a 7.45pm kick-off from the Theatre of Dreams.
In another rematch of last season’s quarter-final, where Wolves triumphed 2-0 at Molineux, Nuno Espirito Santo’s men are out to continue their recent impressive record against United.
Since Wolves’ promotion they have won two and drawn three of their five matches against United in all competitions including that FA Cup win and a 2-1 Premier League victory in April.
The pair drew 1-1 in their Premier League meeting this season when Ruben Neves cancelled out Anthony Martial’s opener in September’s clash in the west midlands.
Will four-time winners Wolves secure another huge scalp by defeating Ole Gunnar Solskjaer’s side? Or will United take care of business at home and march on in their bid to secure a 13th FA Cup that would see them draw level with Arsenal?
A place in the hat and an away tie against Watford or Tranmere Rovers is up for grabs. If you’re not yet a subscriber we can get you signed up in just 15 minutes right here.