The United captain is set to return for Van Gaal's side but Radamel Falcao remains sidelined.
Jack Wilshere has been added to Arsenal's lengthy injury list but Arsene Wenger is hoping to welcome back Olivier Giroud "miles ahead of schedule" in the coming weeks.
Rio Ferdinand appeared to endorse a tweet sent on Friday accusing the Football Association of applying double standards in handing him a three-match ban.
Liverpool captain Steven Gerrard is keen to continue his career beyond this season and admits he may be forced to move away from Anfield if the club fails to offer him a new deal.
Newcastle boss Alan Pardew has warned his players few of them can count on their place in his team after his understudies took centre-stage.
Stoke manager Mark Hughes feels the Football Association's decision not to charge Garry Monk could have set a dangerous precedent.
Defender Alex Bruce is desperate for Hull to get their own back on "bogey team" Southampton.
Everton remain with the same quartet of players unavailable ahead of Saturday's Barclays Premier League clash with Swansea at Goodison Park.