Goals from Amalfitano and Sakho secure West Ham a 2-1 win over Man City at Upton Park.
Leeds' managerial circus returned on Saturday night as trigger-happy owner Massimo Cellino parted company with Darko Milanic after six games in charge.
Wilfried Bony scored both goals as Swansea saw off Leicester 2-0 at the Liberty Stadium on Saturday evening.
Alexis Sanchez made the most of howlers from Wes Brown and Vito Mannone as Arsenal claimed a 2-0 victory at Sunderland.
Saido Berahino's injury-time penalty rescued a point for West Brom as they fought back from two goals down to draw 2-2 with Crystal Palace.
Real Madrid overcame Neymar's early opening goal to see off arch rivals Barcelona 3-1 at the Bernabeu as Luis Suarez made his long-awaited debut for Barca.
Luke Shaw will put aside any feelings he has for Chelsea on Sunday and concentrate instead on proving why Manchester United paid £28million for his services.
Head coach Mauricio Pochettino has warned his Tottenham players to beware the wounded beast this weekend.