The action begins on BT Sport 1 HD and BT Sport 4K UHD from 7.30pm as Saunders attempts to put a miserable 2018 behind him by becoming a two-weight world champion with victory over German visitor Shefat Isufi for the WBO super-middleweight championship.
Joe Joyce will also make his first outing since signing a co-promotional deal with Frank Warren last month, taking on dangerous Russian veteran Alexander Ustinov.
British super-bantamweight rivals Brad Foster and Ashley Lane will go toe-to-toe for the coveted Lonsdale belt in the evening's other main attraction, while a crop of promising young fighters including Willy Hutchinson and Boy Jones Jr will also be given the chance to shine in front of thousands at the Lamex Stadium.
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Saunders v Isufi: Fight preview
Billy Joe Saunders appeared to be on the brink of something special having boxed rings around Canadian slugger David Lemieux in his own back yard in front of a hefty crowd inside Montreal’s Bell Place in December 2017.
One judge scored the contest a complete shutout in favour of the Hatfield fighter in what was the third defence of his WBO middleweight crown, bewitching pundits across the pond in a dazzling display of skill.
Blockbuster unification bouts against the likes of Canelo Alvarez and Gennady Golovkin looked almost inevitable - but fate had other ideas for the unbeaten 29-year-old as a series of unsavoury incidents hampered his march.
A mandatory title defence against challenger Demetrius Andrade was shelved in October last year after Saunders tested positive for the banned performance-enhancing stimulant oxilofrine in the weeks leading up to the fight.
In a statement, Saunders said the negative test was a result of using “a common decongestant nasal spray” but later vacated the title.
Around the same time, Saunders landed himself in hot water with the British Boxing Board of Control after a controversial video circulated on social media that resulted in him receiving a severe reprimand and a £100,000 fine.
The 27-0 (13 KO) fighter subsequently took some time away from the spotlight before returning to make his super-middleweight debut against Charles Adamu on the Josh Warrington v Carl Frampton undercard in December.
A fourth round stoppage proved he was able to carry his power against a durable opponent and placed Saunders in position to challenge for another world title, targeting the vacant 168lb WBO strap.
However, Saturday’s opponent, Shefat Isufi, arrives at the Lamex Stadium with ambitions of his own and will enter the contest with some serious momentum having picked up 10 consecutive victories.
"Listen, a lot of people are looking at him and underestimating him a little bit,” Saunders said.
“I am looking at him and I can, from studying him, see that what he does he does really well. He is not appealing on the eye, but he is better than he actually looks.
"He is obviously No.1 in the world for something and he has got to be taken care of professionally. I have been working hard and I am going to get the job done.
"He is unbeaten at the weight and he has cemented his No.1 spot for a reason. I've got to take him seriously but, at the same time, it is hard not to look past him because I lost my world title without getting beat and I want to be world champion as quickly as I can."
Speaking in the build-up, Serbian-born fighter Isufi revealed how the recent loss of his father had given him the extra drive to succeed in Stevenage.
"I promised my father on his death bed that I would be a world champion and this is my chance,” he explained.
"Billy can have a million people cheering him on, there’s only going to be two of us in that ring on fight night. I will give Billy Joe a very tough night.
"Billy is very good fighter, very fast and quick and a good puncher but I am very confident I will give him a tough time."
Saunders v Isufi: Who else is fighting?
Eyeballs will be drawn to the evening’s heavyweight attraction as Olympic silver medallist Joe Joyce welcomes Russian veteran Alexander Ustinov back to England for the third time.
Victory over the 42-year-old would see Joyce add yet another world title challenger to his increasingly impressive resume after clobbering former WBC king Bermane Stiverne in six rounds last time out.
Ustinov comes into the bout on the back of two losses, to Manuel Charr and Michael Hunter respectively, but remains a dangerous puncher if given space to operate as his record of 25 knockouts in 34 victories would indicate.
“I could have waited until the big fight night on July 13th, but I wanted to keep busy,” Joyce, 33, explained.
“I didn’t want a journeyman, so we chose a 6 foot 8 inch giant and former world heavyweight title challenger Alexander Ustinov who’s only lost 3 times.
“He is big, awkward and he can punch. My aim is to take him out in spectacular fashion and put on a great show for the fans at the Lamex stadium.”
Ustinov, who was once scheduled to face Tyson Fury as a late replacement for the injured Dereck Chisora in 2014 before the fight was cancelled altogether, has won on both of his two previous visits to the UK, beating Travis Walker and Raphael Zumbano Love.
However, with The Juggernaut seeking a ninth consecutive stoppage in his ninth outing, the odds appear stacked against Ustinov hearing the final bell.
Elsewhere on the card, British super-bantamweight champion Brad Foster looks to add the commonwealth strap to his collection of silverware when he takes on Ashley Lane at the Lamex.
Foster, another recent addition to Frank Warren’s Queensbury stable, believes a win on Saturday night should provide him with the perfect platform from which to continue climbing the prizefighter ranks.
"Hopefully I will be at the top one day," added Foster, who acknowledges that he has come a long way in a short space of time.
"It still hasn't sunk in to be honest. I am just Brad from Lichfield, but if I keep on believing in myself then the sky is the limit really.
"Ashley is Commonwealth champion and I am not going to take him lightly. He will want to win the British title because everybody does and my job is just to stop him and pick up the Commonwealth on the way.
"I have looked at him to see his style but I try to focus on myself and to make sure I am the best I can be on the night. The best Brad will beat Ashley Lane."
Ryan 'The Piranha' Garner returns to the ring for his ninth professional fight this weekend. The exciting 21-year-old from Southampton has recorded six KOs from his eight fights so far and is looking to get himself in title contention this year.
Former world amateur champion Willy Hutchinson will have his eighth pro fight in what will be his fifth fight inside a year as the Scot gathers experience in the light heavyweight division, while cruiserweight James Branch Jr, from Hainault, enters into his fifth pro fight seeking a first KO finish.
Unbeaten super lightweight Sanjeev Sahota looks to build on his 11 wins so far with an appearance in Stevenage while gym-mate Harley Benn will be having his seventh fight at super welterweight.
Long-standing Team GB servant Harvey Horn from Chigwell continues building towards domestic flyweight title action with his sixth pro fight.
In a further special attraction on the night, the multi-titled standout amateur star Lisa Whiteside is set to turn professional and will make her debut at the Lamex Stadium.
The decorated flyweight - a natural rival for Nicola Adams in the pro ranks - is a seven-time national champion and a 2018 Commonwealth Games gold medallist, who also won silver at the 2014 world championships, having won bronze at the 2012 edition.
She is also a European championship silver medallist from 2011.
Also featuring on the bill is Streatham super bantamweight Chris Bourke (2-0), Hitchin super middleweight Graham Tirrell (9-0), London light heavyweight Ollie Pattinson (9-0), Aylesbury light heavyweight Adi Burden (8-0) and Milton Keynes middleweight Conor Wright (7-0).
Saunders v Isufi: Selected odds
Billy Joe Saunders 1/100 v Shefat Isufi 18/1
Joe Joyce 1/50 v Alexander Ustinov 14/1
All odds correct with Bet365 at the time of writing